Primary antibody deficiencies: recognition, clinical diagnosis and referral of patients

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Primary antibody deficiencies: recognition, clinical diagnosis and referral of patients.

The primary antibody deficiency syndromes are a rare group of immunodeficiencies where diagnostic delay remains common due to limited awareness of the existence and heterogeneity of their presenting features. Referral for specialist assessment leads to earlier diagnosis and appropriate therapy to prevent or limit structural organ and tissue damage. Greater education of healthcare professionals ...

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Recognition, Clinical Diagnosis and Management of Patients With Primary Antibody Deficiencies: A Systematic Review

METHODS. Computer literature searches were conducted for randomized clinical trials in medical literature databases including the US National Library of Medicine (Medline), the Excerpta Medica database (EMBASE), the Cochrane Library, the Database of Abstracts of Reviews of Effects (DARE) of the Centre for Reviews and Dissemination (University of York), and the Cumulative Index to Nursing and Al...

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Recognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review.

The primary purpose of this systematic review was to produce an evidence-based review of the literature as a means of informing current clinical practice in the recognition, diagnosis and management of patients with suspected primary antibody deficiency. Randomized controlled trials (RCTs) were identified from a search of MEDLINE, EMBASE, The Cochrane Library, DARE (CRD website) and CINAHL by c...

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Impact of delayed diagnosis in children with primary antibody deficiencies.

BACKGROUND Primary antibody deficiencies (PADs) are heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections. To evaluate the diagnostic delay in Iranian PADs in association with their infections, we scored such manifestations to find an association between such delay and the scoring system. METHODS Forty-eight patients with...

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family study of pediatric patients with primary antibody deficiencies.

common variable immunodeficiency (cvid) and selective iga deficiency (sigad) are the most common primary antibody deficiencies. these two diseases may have coincidence in one family and sigad can progress to cvid which suggest common underlying genetic defects between sigad and cvid. this study was designed to find the prevalence of multiple cases in families of iranian patients with cvid or si...

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ژورنال

عنوان ژورنال: Clinical Medicine

سال: 2009

ISSN: 1470-2118,1473-4893

DOI: 10.7861/clinmedicine.9-6-595